Cytokeratin 5 (S573) polyclonal Antibody | BS1208

Cytokeratin 5 (S573) polyclonal Antibody | BS1208 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background: Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. Cytokeratin 5 is expressed in normal basal cells. Mutations of the Cytokeratin 5 gene (KRT5) have been shown to result in the autosomal dominant disorder epidermolysis bullosa (EB) .

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Cytokeratin 5 (S573) polyclonal Antibody detects endogenous levels of Cytokeratin 5 protein.

Molecular Weight: ~ 62 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Keratin, type II cytoskeletal 5; 58 kDa cytokeratin; Cytokeratin-5; Cytokeratin5; Short name=CK-5; CK5; Keratin-5; Keratin5; Keratin 5; Short name=K5; Type-II keratin Kb5; KRT5

Immunogen: Synthetic peptide, corresponding to amino acids 550-600 of Human Cytokeratin 5.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Contribution of Soluble Factors to EMT,