Cytokeratin 6 polyclonal Antibody | BS90385

Cytokeratin 6 polyclonal Antibody | BS90385 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ICC/IF IHC

Application Range: WB:1:1,000-1:2,000 ICC:1:100-1:500 IHC:1:50-1:200

Background: Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins, which are useful markers of tissue differentiation, also aid in the characterization of malignant tumors. IL-1 and TNFα induce transcription of cytokeratin 6 in epidermal keratinocytes via the C/EBP β transcription factor. In humans, multiple isoforms of cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Cytokeratin 6 polyclonal Antibody detects endogenous levels of Cytokeratin 6 protein.

Molecular Weight: 60 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CK-6A, CK-6D, K6A, KRT6A, CK-6B, K6B, KRT6B, CK-6C, CK-6E, K6C, KRT6C, CK 6A, CK 6B, CK 6C, CK 6D, CK 6E, CK-6C, CK-6E, Cytokeratin 6a, Cytokeratin 6B, Cytokeratin 6C, Cytokeratin 6D, Cytokeratin 6E, Cytokeratin-6C, Cytokeratin-6E, K2C6C, K6a keratin, K6b keratin, K6C, K6c keratin, K6d keratin, K6e keratin, Keratin, Keratin K6h, Keratin type II cytoskeletal 6A, Keratin type II cytoskeletal 6B, Keratin type II cytoskeletal 6C, Keratin type II cytoskeletal 6D, Keratin type II cytoskeletal 6E, Keratin-6C, KRT6A, KRT6B, KRT6C, KRT6D, KRT6E, type II cytoskeletal 6C, Type-II keratin Kb12,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: