Cytokeratin 8 Antibody [SB37b] (HRP) | 99-627

Cytokeratin 8 Antibody [SB37b] (HRP) | 99-627 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Homology: N/A

Immunogen: Recombinant C-terminal cytokeratin 8

Research Area: Cancer

Tested Application: Flow, IP

Application: Cytokeratin 8 Antibody [SB37b] for use in immunohistochemistry / immunocytochemistry, ELISA, and western blotting assays.

Specificiy: Cytokeratin 8

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [SB37b]

Isotype: IgG2a

Conjugate: HRP

Physical State: Liquid

Buffer: Supplied in a stock solution of 50% glycerol/50% PBS, pH 7.4; No preservative added

Concentration: Lot specific

Storage Condition: Store vial at 2-8˚C

Alternate Name: CK 8, keratin 8

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1-8) . The two keratin types share only 30% sequence homology. Keratins demonstrate tissue- and differentiation-specific expression profiles. Cytokeratin 8 belongs to the type B (basic) subfamily of keratins and exists in combination with keratin 18. It is expressed in all simple type epithelia tissues (e.g., liver, pancreas, kidney, gut epithelial lining) but not in stratified squamous epithelia. Cytokeratin 8 is also present in the majority of adenocarcinomas and ductal carcinomas but is absent in most squamous cell carcinomas.