Cytostatin sodium | B1240

Cytostatin is a potent and selective protein phosphatase 2A (PP2A) inhibitor. Cell adhesion inhibitor. Inhibits the adhesion of B16 melanoma cells to laminin and collagen type IV in a dose dependent manner but not to fibronectin. Acts as an antitumor and antimetastatic agent. Induces apoptosis.

Cytostatin is a potent and selective protein phosphatase 2A (PP2A) inhibitor. Cell adhesion inhibitor. Inhibits the adhesion of B16 melanoma cells to laminin and collagen type IV in a dose dependent manner but not to fibronectin. Acts as an antitumor and antimetastatic agent. Induces apoptosis.

B1240 | Cytostatin sodium DataSheet

Alternate Name/Synonyms: 5S,6S)-5,6-dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrien-1-yl]-5-methyl-2H-pyran-2-one, monosodium salt

Appearance: Yellowish solid

Formulation: N/A

CAS Number: 457070-06-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: Yes

Molecular Formula: C₂₁H₃₂O₇P • Na

Molecular Weight: 450.4

Cell-Permeable?: Yes

Purity: ≥75% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective protein phosphatase 2A (PP2A) inhibitor.

MDL Number: N/A

PubChem CID: 23675948

SMILES: C/C=C/C=C/C=C/C(C(C)C(CCC(C)C1C(C=CC(=O)O1)C)OP(=O)(O)[O-])O.[Na+]

InChi: InChI=1S/C21H33O7P.Na/c1-5-6-7-8-9-10-18(22)17(4)19(28-29(24,25)26)13-11-15(2)21-16(3)12-14-20(23)27-21;/h5-10,12,14-19,21-22H,11,13H2,1-4H3,(H2,24,25,26);/q;+1/p-1/b6-5+,8-7+,10-9+;

InChi Key: DXWSCXWALSKXSD-GTQQMNRMSA-M