CZC-25146 | B2941

CZC-25146 is a potent inhibitor of Leucine-rich repeat kinase 2 (LRRK2) with an IC₅₀ of 4.76 nM. Mutations in LRRK2 are associated with Parkinson's disease. CZC-25146 attenuates LRRK2 G2019S mutant induced neuronal injury with EC₅₀ values of ~100 nM and 4 nM in primary rodent and human neurons respectively.

CZC-25146 is a potent inhibitor of Leucine-rich repeat kinase 2 (LRRK2) with an IC₅₀ of 4.76 nM. Mutations in LRRK2 are associated with Parkinson's disease. CZC-25146 attenuates LRRK2 G2019S mutant induced neuronal injury with EC₅₀ values of ~100 nM and 4 nM in primary rodent and human neurons respectively.

B2941 | CZC-25146 DataSheet

Alternate Name/Synonyms: N-[2-[[5-Fluoro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanesulfonamide; N-[2-[[5-fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-methanesulfonamide

Appearance: A crystalline solid

Formulation:

CAS Number: 1191911-26-8

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₂H₂₅FN₆O₄S

Molecular Weight: 488.54

Cell-Permeable?: True

Purity: >98%

Solubilities: ~10 mg/ml in DMSO and DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of LRRK2

MDL Number:

PubChem CID: 44252884

SMILES: COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)F

InChi: InChI=1S/C22H25FN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27)

InChi Key: XXHHOTZUJIXPJX-UHFFFAOYSA-N