CZC-54252 hydrochloride | 9567

CZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC₅₀ values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). CZC-54252 attenuates neuronal injury induced by LRRK2-G2019S

CZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC₅₀ values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). CZC-54252 attenuates neuronal injury induced by LRRK2-G2019S

9567 | CZC-54252 hydrochloride DataSheet

Alternate Name/Synonyms: N-[-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide hydrochloride

Appearance: Yellow solid

Formulation: N/A

CAS Number: 1191911-27-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₅ClN₆O₄S.HCl

Molecular Weight: 541.45

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent leucine-rich repeat kinase 2 (LRRK2) inhibitor

MDL Number: N/A

PubChem CID: 90488950

SMILES: COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)Cl.Cl

InChi: InChI=1S/C22H25ClN6O4S.ClH/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31;/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);1H

InChi Key: KWCBHUPLQMUKAF-UHFFFAOYSA-N