D4476 | 1770

A cell-permeable, ATP-competitive inhibitor of casein kinase 1 (CK1) (IC₅₀ = 0.3 µM). Also inhibits ALK5 (IC₅₀ = 0.5 µM) and p38ɑMAP kinase (IC₅₀ = 12 µM). Displays selectivity over many other protein kinases.

D4476 is a cell-permeable, ATP-competitive inhibitor of casein kinase 1 (CK1) (IC₅₀ = 0.3 µM). Also inhibits ALK5 (IC₅₀ = 0.5 µM) and p38ɑMAP kinase (IC₅₀ = 12 µM). Displays selectivity over many other protein kinases.

1770 | D4476 DataSheet

Alternate Name/Synonyms: 4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl) -1H-imidazol-2-yl]benzamide

Appearance: Off-white solid

Formulation: N/A

CAS Number: 301836-43-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₁₈N₄O₃

Molecular Weight: 398.41

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (100 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A casein kinase (CK) inhibitor

MDL Number: MFCD09037526

PubChem CID: 6419753

SMILES: C1COC2=C(O1)C=CC(=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5

InChi: InChI=1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27)

InChi Key: DPDZHVCKYBCJHW-UHFFFAOYSA-N