DAAM1 Antibody (N-term) [AMM08613G]

DAAM1 Antibody (N-term) [AMM08613G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This DAAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-74 amino acids from the N-terminal region of human DAAM1.

Cellular Localisation: Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Note=Perinuclear

Molecular Weight: 123473

Clone: Polyclonal

Gene Name: DAAM1

Gene ID: 23002

Function: Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208) . Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity) . Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity) .

Summary: Tissue Location: Expressed in all tissues examined.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Disheveled-associated activator of morphogenesis 1, DAAM1, KIAA0666