DAB2 Polyclonal Antibody | BS65935

DAB2 Polyclonal Antibody | BS65935 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Guinea Pig,

Application: FCM,

Application Range: Flow-Cyt=1ug/Test

Background: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: DAB2 Polyclonal Antibody detects endogenous levels of DAB2 protein.

Molecular Weight: 82kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: DAB 2; DAB2; DAB2_HUMAN； Differentially expressed protein 2; Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein) ; disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein) ; Disabled homolog 2; Disabled homolog 2 mitogen responsive phosphoprotein (Drosophila) ; Disabled homolog 2 mitogen responsive phosphoprotein; disabled homolog 2 mitogen-responsive phosphoprotein (Drosophila) ; DOC 2; DOC2; FLJ26626; Mitogen responsive phosphoprotein.

Immunogen: KLH conjugated synthetic peptide derived from human DAB2:31-130/770

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: