Dabigatran Etexilate | B2552

Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM. Dabigatran selectively and reversibly inhibits human thrombin (Ki = 4.5 nM) as well as thrombin-induced platelet aggregation (IC50 = 10 nM), while showing no inhibitory effect on other platelet-stimulating agents. Dabigatran displays concentration-dependent anticoagulant effects in various species in vitro.

Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM. Dabigatran selectively and reversibly inhibits human thrombin (Ki = 4.5 nM) as well as thrombin-induced platelet aggregation (IC50 = 10 nM), while showing no inhibitory effect on other platelet-stimulating agents. Dabigatran displays concentration-dependent anticoagulant effects in various species in vitro.

B2552 | Dabigatran Etexilate DataSheet

Alternate Name/Synonyms: BIBR 953, (E)-ethyl 3-(2-(((4-(N'-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate, BIBR953, Pradaxa, BIBR-953

Appearance: Crystalline solid

Formulation:

CAS Number: 211915-06-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form:

Molecular Formula: C₃₄H₄₁N₇O₅

Molecular Weight: 627.73

Cell-Permeable?: True

Purity: ≥98%

Solubilities: 0.5 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A reversible and selective, direct thrombin inhibitor (DTI)

MDL Number:

PubChem CID: 6445226

SMILES: CCCCCCOC(=O)N=C(C1=CC=C(C=C1)NCC2=NC3=C(N2C)C=CC(=C3)C(=O)N(CCC(=O)OCC)C4=CC=CC=N4)N

InChi: InChI=1S/C34H41N7O5/c1-4-6-7-10-21-46-34(44)39-32(35)24-12-15-26(16-13-24)37-23-30-38-27-22-25(14-17-28(27)40(30)3)33(43)41(20-18-31(42)45-5-2)29-11-8-9-19-36-29/h8-9,11-17,19,22,37H,4-7,10,18,20-21,23H2,1-3H3,(H2,35,39,44)

InChi Key: KSGXQBZTULBEEQ-UHFFFAOYSA-N