Dalcetrapib | 2419

Dalcetrapib is a potent CETP modulator. It is a thioester pro-drug that is rapidly hydrolyzed to generate a pharmacologically active thiol. Dalcetrapib modulates cholesteryl ester transfer protein (CETP) activity to raise high-density lipoprotein cholesterol (HDL-C). It achieves 50% inhibition of CETP activity in human plasma at a concentration of 9 μM.

Dalcetrapib is a potent CETP modulator. It is a thioester pro-drug that is rapidly hydrolyzed to generate a pharmacologically active thiol.

2419 | Dalcetrapib DataSheet

Alternate Name/Synonyms: S-2-(1-(2-ethylbutyl)cyclohexanecarboxamido)phenyl 2-methylpropanethioate; JTT-705; RO4607381

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 211513-37-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₃₅NO₂S

Molecular Weight: 389.59

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (>50 mg/ml) or EtOH (>50 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A CETP inhibitor

MDL Number: N/A

PubChem CID: 6918540

SMILES: CCC(CC)CC1(CCCCC1)C(=O)NC2=CC=CC=C2SC(=O)C(C)C

InChi: InChI=1S/C23H35NO2S/c1-5-18(6-2)16-23(14-10-7-11-15-23)22(26)24-19-12-8-9-13-20(19)27-21(25)17(3)4/h8-9,12-13,17-18H,5-7,10-11,14-16H2,1-4H3,(H,24,26)

InChi Key: YZQLWPMZQVHJED-UHFFFAOYSA-N