Dantrolene sodium | 2491

Dantrolene sodium is an inhibitor of Ca²⁺ release from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Acts asa skeletal muscle relaxant that depresses excitation-contraction coupling in skeletal muscle by binding to the type 1 ryanodine receptor and decreasing free intracellular calcium concentration.

Dantrolene sodium is an inhibitor of Ca²⁺ release from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2.

2491 | Dantrolene sodium DataSheet

Alternate Name/Synonyms: 1-​[[[5-​(4-​nitrophenyl)-​2-​furanyl]methylene]amino]-​2,​4-​imidazolidinedione,​ monosodium salt

Appearance: Orange solid

Formulation: N/A

CAS Number: 14663-23-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₄H₉N₄NaO₅

Molecular Weight: 336.23

Cell-Permeable?: No

Purity: ≥98%

Solubilities: DMSO (~ 2.5 mg/ml) or DMF (~ 12.0 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: Blocker of Ca²⁺ uptake and release from sarcoplasmic reticulum

MDL Number: MFCD00079130

PubChem CID: 6604100

SMILES: C1C(=O)N=C(N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].[Na+]

InChi: InChI=1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;

InChi Key: KSRLIXGNPXAZHD-HAZZGOGXSA-M