Danusertib | B1937

Danusertib (PHA-739358) is a potent pan-aurora kinase inhibitor with IC₅₀ values of 13, 79, and 61 nM for Aurora A, B, and C, respectively. It modestly inhibits Abl, TrkA, c-RET and FGFR1, and weakly inhibits Lck, VEGFR2/3, c-Kit, CDK2, etc.

Danusertib (PHA-739358) is a potent pan-aurora kinase inhibitor with IC₅₀ values of 13, 79, and 61 nM for Aurora A, B, and C, respectively. It modestly inhibits Abl, TrkA, c-RET and FGFR1, and weakly inhibits Lck, VEGFR2/3, c-Kit, CDK2, etc.

B1937 | Danusertib DataSheet

Alternate Name/Synonyms: N-[5-[(2R)-2-methoxy-2-phenylacetyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide; PHA-739358

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 827318-97-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₃₀N₆O₃

Molecular Weight: 474.55

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent pan-aurora kinase inhibitor

MDL Number: N/A

PubChem CID: 11442891

SMILES: CN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=NNC4=C3CN(C4)C(=O)C(C5=CC=CC=C5)OC

InChi: InChI=1S/C26H30N6O3/c1-30-12-14-31(15-13-30)20-10-8-19(9-11-20)25(33)27-24-21-16-32(17-22(21)28-29-24)26(34)23(35-2)18-6-4-3-5-7-18/h3-11,23H,12-17H2,1-2H3,(H2,27,28,29,33)/t23-/m1/s1

InChi Key: XKFTZKGMDDZMJI-HSZRJFAPSA-N