Cell permeable. A potent inhibitor of γ-secretase (IC₅₀ = 115 nM for total β-amyloid, IC₅₀ = 200 nM for β-amyloid 1-42). It reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young and...
A 10 mM (5 mg in 1156 µl) solution of γ-secretase inhibitor DAPT (Cat. No.1855) in anhydrous DMSO.DAPT is a potent inhibitor of γ-secretase (IC₅₀ = 115 nM for total β-amyloid, IC₅₀ = 200 nM for...