Dasatinib (BMS-354825, Sprycel) | 1586

Dasatinib is a multi-kinase inhibitor with potent activity against BCR–ABL kinase (IC₅₀ <1 nM) and Src family kinases (IC₅₀ = 0.2–1.1 nM). Dasatinib also inhibits Lyn (IC₅₀ = 8.5 nM) and Src (IC₅₀ = 3.0 nM) kinase activities in vitro using 0.1 mg/mL poly (Glu4-Tyr) as the substrate.

Dasatinib is a multi-kinase inhibitor with potent activity against BCR–ABL kinase (IC₅₀ <1 nM) and Src family kinases (IC₅₀ = 0.2–1.1 nM). Dasatinib also inhibits Lyn (IC₅₀ = 8.5 nM) and Src (IC₅₀ = 3.0 nM) kinase activities in vitro using 0.1 mg/mL poly (Glu4-Tyr) as the substrate.

1586 | Dasatinib (BMS-354825, Sprycel) DataSheet

Alternate Name/Synonyms: BMS-354825, Sprycel

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 302962-49-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₆ClN₇O₂S

Molecular Weight: 488.01

Cell-Permeable?: Yes

Purity: ≥99% by HPLC

Solubilities: DMSO (200 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A multi-kinase inhibitor selective to Bcr-Abl and Src

MDL Number: MFCD11046566

PubChem CID: 3062316

SMILES: CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C

InChi: InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33- 17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H, 6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)

InChi Key: ZBNZXTGUTAYRHI-UHFFFAOYSA-N