DBC1 (3G4) monoclonal Antibody | MB0057

DBC1 (3G4) monoclonal Antibody | MB0057 | Gentaur UK, US & Europe Distribution

Host: Mouse IgG1

Reactivity: Human,Mouse,Rat,Monkey

Application: WB ICC IP

Application Range: WB: 1:500~1000 ICC: 1:50~200

Background: Core component of the DBIRD complex,a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing:the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T) -rich DNA regions.Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis.Inhibits SUV39H1 methyltransferase activity.As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This Antibody detects endogenous levels of DBC1 and does not cross-react with related proteins

Molecular Weight: Predicted band size:103KDa Observed band size:120KDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: DBC1; DBC-1; NET35; p30DBC; p30 DBC; DBC.1; DBIRD complex subunit; KIAA1967

Immunogen: Synthetic peptide, corresponding to the N-terminus of Human KIAA1967.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: