DBN1 Antibody (Center) [APR33475G]

DBN1 Antibody (Center) [APR33475G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This DBN1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 194-228 amino acids from the Central region of human DBN1.

Cellular Localisation: Cytoplasm. Cell projection, dendrite. Cytoplasm, cell cortex. Cell junction. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9QXS6}. Note=In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm (PubMed:20215400) . In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (PubMed:20215400) . Colocalized with RUFY3 and F-actin at the transitional domain of the axonal growth cone (By similarity) {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}

Molecular Weight: 71429

Clone: Polyclonal

Gene Name: DBN1

Gene ID: 1627

Function: Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400) . Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400) . Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity) . Involved in memory-related synaptic plasticity in the hippocampus (By similarity) .

Summary: Tissue Location: Expressed in the brain, with expression in the molecular layer of the dentate gyrus, stratum pyramidale, and stratum radiatum of the hippocampus (at protein level) (PubMed:8838578) . Also expressed in the terminal varicosities distributed along dendritic trees of pyramidal cells in CA4 and CA3 of the hippocampus (at protein level) (PubMed:8838578) . Expressed in pyramidal cells in CA2, CA1 and the subiculum of the hippocampus (at protein level) (PubMed:8838578) Expressed in peripheral blood lymphocytes, including T-cells (at protein level) (PubMed:20215400) . Expressed in the brain (PubMed:8216329, Ref.2) . Expressed in the heart, placenta, lung, skeletal muscle, kidney, pancreas, skin fibroblasts, gingival fibroblasts and bone-derived cells (Ref.2) {ECO:0000269|PubMed:20215400, ECO:0000269|PubMed:8216329, ECO:0000269|PubMed:8838578, ECO:0000269|Ref.2}

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Drebrin, Developmentally-regulated brain protein, DBN1, D0S117E