DBZ | 2649

DBZ is a potent γ-secretase inhibitor that blocks the cleavage of Notch into its active signaling effector, Notch intracellular domain, in human T cell lymphoma (SupT1) cells (IC₅₀ = 1.7 nM).

DBZ is a potent γ-secretase inhibitor that blocks the cleavage of Notch into its active signaling effector, Notch intracellular domain, in human T cell lymphoma (SupT1) cells (IC₅₀ = 1.7 nM).

2649 | DBZ DataSheet

Alternate Name/Synonyms: N-​[(1S)-​2-​[[(7S)-​6,​7-​dihydro-​5-​methyl-​6-​oxo-​5H-​dibenz[b,​d]azepin-​7-​yl]amino]-​1-​methyl-​2-​oxoethyl]-​3,​5-​difluoro-​benzeneacetamide

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 209984-56-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₂₃F₂N₃O₃

Molecular Weight: 463.48

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 35 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent γ-secretase inhibitor

MDL Number: N/A

PubChem CID: 11454028

SMILES: CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F

InChi: InChI=1S/C26H23F2N3O3/c1-15(29-23(32)13-16-11-17(27)14-18(28)12-16)25(33)30-24-21-9-4-3-7-19(21)20-8-5-6-10-22(20)31(2)26(24)34/h3-12,14-15,24H,13H2,1-2H3,(H,29,32)(H,30,33)/t15-,24-/m0/s1

InChi Key: QSHGISMANBKLQL-OWJWWREXSA-N