DCC Antibody (C-term) [APR33091G]

DCC Antibody (C-term) [APR33091G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This DCC antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1048-1082 amino acids from the C-terminal region of human DCC.

Cellular Localisation: Membrane; Single-pass type I membrane protein.

Molecular Weight: 158457

Clone: Polyclonal

Gene Name: DCC

Gene ID: 1630

Function: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

Summary: Tissue Location: Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Netrin receptor DCC, Colorectal cancer suppressor, Immunoglobulin superfamily DCC subclass member 1, Tumor suppressor protein DCC, DCC, IGDCC1