DCLRE1B polyclonal Antibody | BS62352

DCLRE1B polyclonal Antibody | BS62352 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: DNA interstrand cross-links (ICLs) pose lethal threats to DNA as they inhibit segregation, replication and transcription. The mechanism of ICL repair is complex but is at least partly conserved between Saccharomyces cerevisiae and mammals. SNM1B (SNM1 homolog B), also known as DCLRE1B [DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae]) or APOLLO, is a 532 amino acid nuclear protein that localizes to discrete foci and is likely required for DNA interstrand cross-link repair. SNM1B assists in the maintenance of telomeres during S-phase and interacts with TRF2 (telomeric repeat binding factor 2), a protein involved in telomeric organization and protection, in the early DNA-damage response. A member of the DNA repair metallo-β-lactamase (DRMBL) family, SNM1B becomes phosphorylated following translation, either by ATM or ATR, and is encoded by a gene located on human chromosome 1.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: DCLRE1B polyclonal Antibody detects endogenous levels of DCLRE1B protein.

Molecular Weight: ~ 60 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: 5' exonuclease Apollo; DNA cross-link repair 1B protein; SNM1 homolog B; SNMIB; hSNM1B; DCLRE1B; SNM1B

Immunogen: Synthetic peptide, corresponding to Human DCLRE1B.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: