Dcp1a polyclonal Antibody | BS90396

Dcp1a polyclonal Antibody | BS90396 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ICC IHC FC

Application Range: WB:1:500-1:2000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: Cleavage of the 5'-cap structure is involved in the major 5'-to-3' and nonsense-mediated mRNA decay pathways. The protein complex consisting of Dcp1 and Dcp2 has been identified as the species responsible for the decapping reaction in Saccharomyces cerevisiae. In nonsense-mediated decay, the human decapping complex, made up of S. cerevisiae homologs Dcp1a and hDcp2, may be recruited to mRNAs containing premature termination codons by nonsense-mediated decay factor (Upf) proteins. hDcp2 specifically hydrolyzes methylated capped RNA to release m (7) GDP, thereby aiding in mRNA degradation. Both Dcp1a and hDcp2 colocalize in the cytoplasm. In addition, Dcp1a interacts with Smad4 forming a complex with TGFβ and BMP-4. Dcp1a and Smad4 interact directly through a EVH1/WH1 domain on Dcp1a and a proline-rich activation domain on Smad4. Smad4 is essential to nuclear translocation of Dcp1a as deletion of the Smad4-interacting domain (located in the N-terminal 100 amino acids) of Dcp1a eliminates TGFβ-induced nuclear translocation of Dcp1a.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: Dcp1a polyclonal Antibody detects endogenous levels of Dcp1a protein.

Molecular Weight: 63 kDa (Predicted band size)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: DCP1A, SMIF, DCP1 decapping enzyme homolog A, Dcp1a, DCP1A, Decapping enzyme hDcp1a, Decapping mRNA 1A, HSA275986, mRNA decapping enzyme 1A, mRNA-decapping enzyme 1A, Nbla00360, Putative protein product of Nbla00360, Smad4 interacting transcriptional co activator, Smad4-interacting transcriptional co-activator, Smad4-interacting transcriptional co-activator, SMAD4IP1 Antibody SMIF, Transcription factor SMIF,

Immunogen: N/A

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: