Dcr-1 Antibody (Center) [APR31861G]

Dcr-1 Antibody (Center) [APR31861G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: E

Specificity: This Dcr-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1068-1097 amino acids of CAEEL Dcr-1.

Cellular Localisation: N/A

Molecular Weight: 218423

Clone: Polyclonal

Gene Name: dcr-1 {ECO:0000303|PubMed:11641272, ECO:0000312|WormBase:K12H4.8}

Gene ID: 176138

Function: Component of the ERI/DICER complex which is involved in processing amplified double-stranded RNA (dsRNA) intermediates during small-RNA-mediated gene-silencing or RNA interference (RNAi) (Probable) . Involved in cleaving dsRNA in the RNAi pathway (PubMed:11641272, PubMed:20223951) . It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs (PubMed:11641272, PubMed:20223951) . Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing (PubMed:11641272) . Required for avoidance behavior induced by small RNAs derived from pathogenic bacteria such as P.aeruginosa (PubMed:32908307) . Involved in innate immunity through its role in small RNA processing.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Endoribonuclease dcr-1, 3126-, dcr-1