DCTN2 Polyclonal Antibody | E-AB-67423

DCTN2 Polyclonal Antibody | E-AB-67423 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: DCTN2, DCTN50, DYNAMITIN, HEL-S-77, RBP50

Application: WB, IHC, IF

Reactivity: Human, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cell Biology, Signal Transduction

Background: This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant fusion protein of human DCTN2 (NP_006391.1).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:20-1:50

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 44 kDa

Molecular Weight(Observed): 44 kDa