DDB1 polyclonal Antibody | BS90398

DDB1 polyclonal Antibody | BS90398 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC/IF IHC IP

Application Range: WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 IP:1:10-1:50

Background: Damaged DNA binding protein (DDB) is a heterodimer composed of two subunits, p127 and p48, which are designated DDB1 and DDB2, respectively. The DDB heterodimer is involved in repairing DNA damaged by ultraviolet light. Specifically, DDB, also designated UV-damaged DNA binding protein (UV-DDB), xeroderma pigmentosum group E binding factor (XPE-BF) and hepatitis B virus X-associated protein 1 (XAP-1), binds to damaged cyclobutane pyrimidine dimers (CPDs) . Mutations in the DDB2 gene are implicated as causes of xeroderma pigmentosum group E, an autosomal recessive disease in which patients are defective in nucleotide excision DNA repair. XPE is characterized by hypersensitivity of the skin to sunlight with a high frequency of skin cancer as well as neurologic abnormalities. The hepatitis B virus (HBV) X protein interacts with DDB1, which may mediate HBx transactivation.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: DDB1 polyclonal Antibody detects endogenous levels of DDB1 protein.

Molecular Weight: 127 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: DDBa, XAP-1, UV-DDB 1, XPE-BF, XPCe, DDB1, XAP1, Damage specific DNA binding protein 1, Damage-specific DNA-binding protein 1, DDB 1, DDB p127 subunit, Ddb1, DDB1, DDBa, DNA damage binding protein 1, DNA damage-binding protein 1, DNA damage-binding protein a, HBV X-associated protein 1, UV damaged DNA binding factor, UV damaged DNA binding protein 1, UV DDB 1, UV DDB1, UV-damaged DNA-binding factor, UV-damaged DNA-binding protein 1, UV-DDB 1, X associated protein 1, XAP 1, XAP-1, XAP1, Xeroderma pigmentosum group E complementing protein, Xeroderma pigmentosum group E-complementing protein, XPCe, XPE, XPE BF, XPE binding factor, XPE-BF, XPE-binding factor,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: