DDR1 Antibody | 13-682

DDR1 Antibody | 13-682 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 290-420 of human DDR1 (NP_054700.2) .

Research Area: Cancer, Immunology, Neuroscience, Signal Transduction

Tested Application: WB

Application: WB: 1:1000 - 1:2000

Specificiy: N/A

Positive Control 1: 293T

Positive Control 2: SW480

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 125kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: DDR1, Cell adhesion kinase, CD167, CD167a antigen, EDDR1, ENTRK4, Mammary carcinoma kinase 10, MCK10, NEP, PTK3, PTK3A, RTK6, Tyrosine-protein kinase CAK, CAK, DDR, Discoidin domain receptor 1, HGK2, MCK-10, NTRK4, Protein-tyrosine kinase 3A, Protein-tyrosine kinase RTK-6, TRK E, TRKE, Tyrosine kinase DDR

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.