Decernotinib (VX-509) | B1260

Decernotinib (VX-509) is a potent and selective JAK3 inhibitor (Ki = 2 nM). it has been shown to dose dependently reduce proinflammatory responses in a rat collagen-induced arthritis model and a mouse model of oxazolone-induced delayed-type hypersensitivity.

Decernotinib (VX-509) is a potent and selective JAK3 inhibitor (Ki = 2 nM). it has been shown to dose dependently reduce proinflammatory responses in a rat collagen-induced arthritis model and a mouse model of oxazolone-induced delayed-type hypersensitivity.

B1260 | Decernotinib (VX-509) DataSheet

Alternate Name/Synonyms: (R,Z)-2-((2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-2-methyl-N-(2,2,2-trifluoroethyl)butanimidic acid

Appearance: Crystaline solid

Formulation: N/A

CAS Number: 944842-54-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₈H₁₉F₃N₆O

Molecular Weight: 392.38

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective JAK3 inhibitor

MDL Number: N/A

PubChem CID: 59422203

SMILES: CCC(C)(C(=O)NCC(F)(F)F)NC1=NC(=NC=C1)C2=CNC3=C2C=CC=N3

InChi: InChI=1S/C18H19F3N6O/c1-3-17(2,16(28)25-10-18(19,20)21)27-13-6-8-23-15(26-13)12-9-24-14-11(12)5-4-7-22-14/h4-9H,3,10H2,1-2H3,(H,22,24)(H,25,28)(H,23,26,27)/t17-/m1/s1

InChi Key: ASUGUQWIHMTFJL-QGZVFWFLSA-N