DEFB4 polyclonal Antibody | BS7188

DEFB4 polyclonal Antibody | BS7188 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB: 1:500~1:2000 IHC: 1:50~1:200 IF: 1:50~1:200

Background: β-defensins (also designated BD, and hBD in human) are small cationic peptides with broad-spectrum antimicrobial activity. Produced in mucosal epithelia and neutrophils of several species, β-defensins are developmentally regulated. Unlike the other previously described human β-defensins, human β-defensin 4 (hBD-4) expression is restricted to a few tissues, with highest expression in testis. A restricted pattern is also exhibited by mouse β-defensin 4. Rat β-defensin 4 (also desiganated BD-4, RBD-4, BD-2, and RBD-2) is developmentally regulated in the lung and is predominantly expressed in the lung and, to a lesser extent, in the trachea and tongue. It exhibits a regulation pattern similar to that of specific genes involved in host defense around the time of birth. The selectivity in both expression pattern and antimicrobial activity of human β-defensin 4 suggests that it is best suited to act at the epithelial locations where it is expressed.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: DEFB4 polyclonal Antibody detects endogenous levels of DEFB4 protein.

Molecular Weight: ~ 8 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Beta-defensin 4A; Beta-defensin 2; BD-2; hBD-2; Defensin beta 2; Skin-antimicrobial peptide 1; SAP1; DEFB4A; DEFB102, DEFB2, DEFB4; DEFB4B; β-defensin 4A; Defensin-β2; Defensin β2

Immunogen: Recombinant full length Human DEFB4.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Jak Stat ：IL-6 Receptor Signaling,Toll-like Receptor signaling,