DEM1 Antibody (Center) [APR30612G]

DEM1 Antibody (Center) [APR30612G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, Ha, M

Specificity: This DEM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-193 amino acids from the Central region of human DEM1.

Cellular Localisation: Nucleus. Cytoplasm, cytosol. Note=Localizes to repair foci in response to DNA damage

Molecular Weight: 41816

Clone: Polyclonal

Gene Name: EXO5

Gene ID: 64789

Function: Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'- directionality activity.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: WB--1:1000

Synonyms: Exonuclease V, Exo V, hExo5, 31--, Defects in morphology protein 1 homolog, EXO5, C1orf176, DEM1