DENR Antibody | 7755

DENR Antibody | 7755 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: Predicted species reactivity based on immunogen sequence: Chicken: (100%) , Bovine: (100%)

Immunogen: DENR antibody was raised against an 18 amino acid peptide near the center of human DENR.
The immunogen is located within amino acids 80 - 130 of DENR.

Research Area: Homeostasis

Tested Application: E, WB, IHC-P, IF

Application: DENR antibody can be used for detection of DENR by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry at 5 μg/mL. For Immunoflorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Specificiy: DENR antibody is human, mouse and rat reactive.

Positive Control 1: Cat. No. 1303 - Human Brain Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 22 kDa
Observed: 22 kDa

Validation: N/A

Isoform: N/A

Purification: DENR antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: DENR Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: DENR antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: DENR Antibody: DRP, DRP1, SMAP-3, H14, Density-regulated protein, Protein DRP1, DRP

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: DENR (density-regulated protein) , also designated DRP or smooth muscle cell associated protein 3 (SMAP-3) , is a 198 amino acid protein that may be involved in the translation of target mRNAs by scanning and recognition of the initiation codon (1) . It plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1 (2, 3) . DENR contains a SUI1 domain and is found in a variety of tissues with highest levels present in skeletal and cardiac muscle. It is up-regulated in ovarian and breast cancer cells by ERBB2 overexpression (4) .