Desipramine hydrochloride | B2987

Desipramine HCl is a tricyclic antidepressant that is a selective inhibitor of norepinephrine transporter with Ki values of 4 nM, 61 nM and 78.72 μM for Norepinephrine Transporter (NET), Serotonin Transporter (SERT) and Dopamine Transporter (DAT) respectively. Rats treated with desipramine (15 mg/kg/day for 14 days) show reduced NET expression. In these rats, the antidepressant-like effect was evident 2 days after discontinuation of desipramine.

Desipramine HCl is a tricyclic antidepressant that is a selective inhibitor of norepinephrine transporter with Ki values of 4 nM, 61 nM and 78.72 μM for Norepinephrine Transporter (NET), Serotonin Transporter (SERT) and Dopamine Transporter (DAT) respectively. Rats treated with desipramine (15 mg/kg/day for 14 days) show reduced NET expression. In these rats, the antidepressant-like effect was evident 2 days after discontinuation of desipramine.

B2987 | Desipramine hydrochloride DataSheet

Alternate Name/Synonyms: 10,11-Dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride; G-35020; JB-8181; Norpramin; Pertofran; 10,11-Dihydro-5-(3-(methylamino)propyl)-5H-dibenz(b,f)azepine monohydrochloride; 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine hydrochloride

Appearance: White to off-white powder

Formulation:

CAS Number: 58-28-6

Structure Available?: True

Peptide sequence:

Salt Form: True

Molecular Formula: C₁₈H₂₃ClN₂

Molecular Weight: 302.84

Cell-Permeable?: False

Purity: 0.98

Solubilities: 50 mg/ml in Water

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: Inhibitor of Norepinephrine transporter

MDL Number: MFCD00058108

PubChem CID: 65327

SMILES: CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31.Cl

InChi: InChI=1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H

InChi Key: XAEWZDYWZHIUCT-UHFFFAOYSA-N