Dexrazoxane | B3369

Dexrazoxane | B3369

Description: Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα. Dexrazoxane could chelate iron to decrease the generation of ROS, thus preventing ROS-induced cardiomyocyte apoptosis. Additionally, dexrazoxane is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury.

Alternate Name/Synonyms: 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-2,6-piperazinedione ICRF 187 NSC 169780

Appearance: White to light yellow to orange powder

Formulation:

CAS Number: 24584-09-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₁H₁₆N₄O₄

Molecular Weight: 268.27

Cell-Permeable?: True

Purity: ≥98% by titration

Solubilities: ~10 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handlinAvoid contact by all modes of exposure.

Tag Line: An intracellular iron chelator

MDL Number: MFCD00866449

PubChem CID: 71384

PubChem CID Link: https://pubchem.ncbi.nlm.nih.gov/compound/71384

SMILES: O=C(N1)CN(C[C@H](C)N2CC(NC(C2)=O)=O)CC1=O

InChi: InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1

InChi Key: BMKDZUISNHGIBY-ZETCQYMHSA-N

Category: Biochemicals