Dextromethorphan (hydrobromide hydrate) | 2912

Dextromethorphan (DXM) is a morphinan with structural similarity to levorphanol, codeine, and morphine. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM). It is a Cytochrome P450 2D6 substrate and it is converted into the active metabolite dextrorphan in the liver.

Dextromethorphan (DXM) is a morphinan used as a cough suppressant. It is a Cytochrome P450 2D6 substrate and it is converted into the active metabolite dextrorphan in the liver.

2912 | Dextromethorphan (hydrobromide hydrate) DataSheet

Alternate Name/Synonyms: (9α,​13α,​14α)-​3-​methoxy-​17-​methyl-​morphinan,​ hydrobromide monohydrate

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 6700-34-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₅NO • HBr [H₂O]

Molecular Weight: 370.3

Cell-Permeable?: N/A

Purity: ≥98%

Solubilities: PBS, pH 7.2 (5 mg/ml), Ethanol or DMF (20 mg/ml), DMSO (12 mg/ml). Organic solvents should be purged in inert gas. Aqueous solutions should not be stored for >1 day.

Handling: Do not take internally. Wear gloves and mask when handling! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A Cytochrome P450 2D6 substrate

MDL Number: MFCD02173901

PubChem CID: 5462351

SMILES: CN1[C@@H]2[C@@]3([H])CCCC[C@@]3(CC1)C4=CC(OC)=CC=C4C2

InChi: InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1

InChi Key: MKXZASYAUGDDCJ-NJAFHUGGSA-N