DGK-δ (S66) polyclonal Antibody | BS2078

DGK-δ (S66) polyclonal Antibody | BS2078 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background: Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DAG) to produce phosphatidic acid. DAG and phosphatidic acid are lipids that act as second messengers in signaling cascades. DGK-α influences cell activation and secretion of lethal exosomes, which in turn control cell death. DGK-β is abundant in restricted brain regions such as the caudate putamen and olfactory tubercle. DGK-γ encodes full-length and truncated transcripts that are present in a range of human tissues, with greatest expression observed in retina. DGK-δ is most abundant in skeletal muscle. DGK-ε shows specificity for arachidonylcontaining diacylglycerol and is expressed predominantly in testis. DGK-θ is most abundant in the cerebellum and hippocampus. DGK-ι is present in brain and retina as a predominant transcript of more than 12 kb, including a long 3-prime untranslated region, with additional low abundance transcripts of 9.5 and 7.5 kb. DGK-η is closely related to DGK-δ. DGK-ζ is most abundant in brain and muscle. DGKs have structural motifs that play regulatory roles, and these motifs form the basis for dividing the DGKs into five subtypes.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: DGK-δ (S66) polyclonal Antibody detects endogenous levels of DGK-δ protein.

Molecular Weight: ~ 135 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Diacylglycerol kinase delta; DAG kinase delta; 130 kDa diacylglycerol kinase; Diglyceride kinase delta; DGK-delta; DGKD; KIAA0145; DGKδ; DGK δ

Immunogen: Synthetic peptide, corresponding to amino acids 34-88 of Human DGK-δ.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: