DGKB Antibody (C-term) [APR07100G]

DGKB Antibody (C-term) [APR07100G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This DGKB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 773-804 amino acids from the C-terminal region of human DGKB.

Cellular Localisation: Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:Q6NS52}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6NS52}. Cell membrane; Peripheral membrane protein. Cytoplasm Note=Translocation to the plasma membrane is induced by phorbol esters

Molecular Weight: 90595

Clone: Polyclonal

Gene Name: DGKB

Gene ID: 1607

Function: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522) . Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) . Has a higher activity with long-chain diacylglycerols like 1, 2-di- (9Z-octadecenoyl) -sn-glycerol compared to 1, 2-didecanoyl-sn-glycerol (By similarity) . Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity) .

Summary: Tissue Location: [Isoform 1]: Specifically expressed in brain but also detected in uterus (PubMed:11719522) . In adult brain, expressed in the amygdala, caudate nucleus, and hippocampus (PubMed:11719522)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Diacylglycerol kinase beta, DAG kinase beta, 90 kDa diacylglycerol kinase, Diglyceride kinase beta, DGK-beta, DGKB, DAGK2, KIAA0718