DHEA | 2172

DHEA is a steroid secreted by the adrenal gland with both estrogenic and androgenic properties. It is a negative modulator of GABAA receptors. DHEA inhibits the activity of G6PD (glucose 6-phosphate dehydrogenase) in a dose-dependent manner with EC₅₀ of 4 μm. However, DHEA does not inhibit the enzymatic activity of PGD (6-phosphogluconate dehydrogenase), the second enzyme in the pentose phosphate pathway.

DHEA is a steroid secreted by the adrenal gland with both estrogenic and androgenic properties. It is a negative modulator of GABAA receptors. DHEA inhibits the activity of G6PD (glucose 6-phosphate dehydrogenase) in a dose-dependent manner with EC₅₀ of 4 μm. However, DHEA does not inhibit the enzymatic activity of PGD (6-phosphogluconate dehydrogenase), the second enzyme in the pentose phosphate pathway.

2172 | DHEA DataSheet

Alternate Name/Synonyms: 5-Dehydroepiandrosterone; Dehydroisoandrosterone; Prasterone

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 53-43-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₈O₂

Molecular Weight: 288.43

Cell-Permeable?: Yes

Purity: ≥99% by TLC

Solubilities: DMSO

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A G6PD (glucose 6-phosphate dehydrogenase) inhibitor

MDL Number: MFCD00003613

PubChem CID: 5881

SMILES: CC12CCC3C(C1CCC2=O)CC=C4C3(CCC(C4)O)C

InChi: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1

InChi Key: FMGSKLZLMKYGDP-USOAJAOKSA-N