DIABLO polyclonal Antibody | BS90408

DIABLO polyclonal Antibody | BS90408 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC/IF IHC IP FC

Application Range: WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: The activation of caspases is a key regulatory step in apoptosis. Once cytochrome c is released from the mitochondria into the cytosol, it binds Apaf-1 to form an oligomeric cytochrome c/Apaf-1 complex, which induces caspase activation. Inhibitors of Apoptosis Proteins (IAPs), are a family of proteins that regulate the cytochrome c/Apaf-1 caspase activating pathway. Like cytochrome c, Smac (for second mitochondria-derived activator of caspase, also designated DIABLO in mouse for direct IAP binding protein with low PI) promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by binding IAPs and preventing them from inhibiting caspases. In healthy cells, Smac is a mitochondrial protein, but when cells undergo apoptosis, Smac is released into the cytosol.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: DIABLO polyclonal Antibody detects endogenous levels of DIABLO protein.

Molecular Weight: 21 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Smac, DIABLO, 0610041G12Rik, DBLOH, DBOH, DFNA64, diablo, Diablo homolog (Drosophila), Diablo homolog, Diablo homolog mitochondrial, Diablo IAP binding mitochondrial protein, Diablo like protein, DIABLO S, Direct IAP binding protein with low pI, Direct IAP-binding protein with low pI, FLJ10537, FLJ25049, mitochondrial, Mitochondrial Smac protein, Second mitochondria derived activator of caspase, Second mitochondria-derived activator of caspase, SMAC 3, Smac, Smac protein, SMAC3,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: Adherens Junction signaling,