DIAPH3 polyclonal Antibody | BS90410

DIAPH3 polyclonal Antibody | BS90410 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Application: WB ICC IHC FC

Application Range: WB:1:500 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: DIAPH3 (diaphanous homolog 3), also known as DIAP3, DRF3 or mDia2 of mouse origin, is a 1,193 amino acid member of the formin homology protein family and is required for the correct function of various cellular processes. DIAPH3 binds to both Profilin, a protein involved in cell maintenance, and to the GTP-bound form of Rho (Rho-GTP) . Binding to both of these proteins allows DIAPH3 to recruit Profilin to the membrane, in a Rho-dependent manner. At the membrane, DIAPH3 promotes Actin polymerization and is required for stress fiber formation, cytokinesis and transcriptional activation of the serum response factor (SRF) . DIAPH3 also regulates Actin dynamics by coupling Src tyrosine kinase (c-Src) and Rho during Actin signaling events. DIAPH3 contains one diaph-anous autoregulatory domain (DAD) and one Rho GTPase-binding domain (GBD) . When DAD and GBD are intramolecularly bound, the GBD is occupied and DIAPH3 is inactive. Interruption of the DAD-GBD bond allows the GBD to bind to Rho-GTP, thus activating DIAPH3. Seven isoforms of DIAPH3 exist due to alternative splicing events.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: DIAPH3 polyclonal Antibody detects endogenous levels of DIAPH3 protein.

Molecular Weight: 137/80 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: DRF3, DIAPH3, DIAP3, AN, AUNA1, Dia2, diap3, DIAP3, DIAPH3, Diaphanous homolog 3 (Drosophila), Diaphanous homolog 3, Diaphanous related formin 3, Diaphanous, Drosophila, homolog of, 3, Diaphanous-related formin-3, DKFZp434C0931, DKFZp686A13178, DRF3, FLJ34705, mDia2, NSDAN, OTTHUMP00000018480, Protein diaphanous homolog 3, RP11-26P21.1,

Immunogen: Synthetic peptide within human DIAPH3 aa 1-50.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Peptide affinity purified.

Pathway: