Dimethyl Fumarate | 9660

Dimethyl fumarate is an anti-inflammatory agent. It effectively blocks NF-κB activity in multiple breast cancer cell lines and abrogates NF-κB-dependent mammosphere formation, indicating that DMF has anti-cancer stem cell properties. In addition, DMF inhibits cell proliferation and significantly impairs xenograft tumor growth. DMF also prevents p65 nuclear translocation and attenuates its DNA binding activity but has no effect on upstream proteins in the NF-κB pathway.

Dimethyl fumarate is an anti-inflammatory agent. It effectively blocks NF-κB activity in multiple breast cancer cell lines and abrogates NF-κB-dependent mammosphere formation, indicating that DMF has anti-cancer stem cell properties. In addition, DMF inhibits cell proliferation and significantly impairs xenograft tumor growth. DMF also prevents p65 nuclear translocation and attenuates its DNA binding activity but has no effect on upstream proteins in the NF-κB pathway.

9660 | Dimethyl Fumarate DataSheet

Alternate Name/Synonyms: 2(E)-Butenedioic acid 1,4-dimethyl ester; DMF

Appearance: White solid

Formulation: N/A

CAS Number: 624-49-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₆H₈O₄

Molecular Weight: 144.13

Cell-Permeable?: Yes

Purity: ≥98% by GC

Solubilities: DMSO (>15 mg/ml) or EtOH (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An anti-inflammatory agent and NF-κB activity blocker

MDL Number: MFCD00064438

PubChem CID: 637568

SMILES: COC(=O)/C=C/C(=O)OC

InChi: InChI=1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+

InChi Key: LDCRTTXIJACKKU-ONEGZZNKSA-N