Dinaciclib | 9537

Dinaciclib is a potent and selective cyclin-dependent kinase (CDK) inhibitor displaying selectivity for CDK1, CDK2, CDK5 and CDK9 with IC₅₀ values of 3, 1, 1 and 4 nM respectively. It has been shown to inhibit DNA synthesis by blocking thymidine incorporation in A2780 ovarian cancer cells with an IC₅₀ value of 4 nM.

Dinaciclib is a potent and selective cyclin-dependent kinase (CDK) inhibitor displaying selectivity for CDK1, CDK2, CDK5 and CDK9 with IC₅₀ values of 3, 1, 1 and 4 nM respectively. It has been shown to inhibit DNA synthesis by blocking thymidine incorporation in A2780 ovarian cancer cells with an IC₅₀ value of 4 nM.

9537 | Dinaciclib DataSheet

Alternate Name/Synonyms: 2-[(2S)-1-[3-ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol; SCH-727965

Appearance: Light brown solid

Formulation: N/A

CAS Number: 779353-01-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₈N₆O₂

Molecular Weight: 396.49

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent CDK inhibitor

MDL Number: N/A

PubChem CID: 46926350

SMILES: CC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCCC4CCO

InChi: InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1

InChi Key: PIMQWRZWLQKKBJ-SFHVURJKSA-N