DIO3 Antibody (C-term) [APR07584G]

DIO3 Antibody (C-term) [APR07584G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, Rat

Specificity: This DIO3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-278 amino acids from the C-terminal region of human DIO3.

Cellular Localisation: Cell membrane; Single-pass type II membrane protein Endosome membrane; Single-pass type II membrane protein

Molecular Weight: 33947

Clone: Polyclonal

Gene Name: DIO3

Gene ID: 1735

Function: Responsible for the deiodination of T4 (3, 5, 3', 5'- tetraiodothyronine) into RT3 (3, 3', 5'-triiodothyronine) and of T3 (3, 5, 3'-triiodothyronine) into T2 (3, 3'-diiodothyronine) . RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.

Summary: Tissue Location: Expressed in placenta and several fetal tissues.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P, WB

Dilution: WB--1:2000

Synonyms: Type III iodothyronine deiodinase, 5DIII, DIOIII, Type 3 DI, Type-III 5'-deiodinase, DIO3, ITDI3, TXDI3