DIS3 Antibody | 7343

DIS3 Antibody | 7343 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: DIS3 antibody was raised against an 18 amino acid peptide near the amino terminus of human DIS3.
The immunogen is located within amino acids 90 - 140 of DIS3.

Research Area: Cancer, Cell Cycle

Tested Application: E, WB, IHC-P, IF

Application: DIS3 antibody can be used for detection of DIS3 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Specificiy: Multiple isoforms of DIS3 are known to exist.

Positive Control 1: Cat. No. 1316 - Human Ovary Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 105 kDa
Observed: 103 kDa

Validation: N/A

Isoform: N/A

Purification: DIS3 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: DIS3 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: DIS3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: DIS3 Antibody: RRP44, dis3p, EXOSC11, KIAA1008, 2810028N01Rik, RRP44, Exosome complex exonuclease RRP44, Protein DIS3 homolog

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: DIS3 Antibody: The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.