Ditolylguanidine | B3044

Ditolylguanidine is a sigma receptor (σR) agonist with neuroprotective activity. It shows Kd values of 21.9 nM and 57.4 nM for σ2 and σ1 receptor respectively. Combined treatment with Ditolylguanidine (5 mg/kg) and memantine induces antidepressant-like effect in rats. Sigma receptor modulators are predicted to show activity against SARS-Cov-2, based on viral assay screens and interaction of the SARS-CoV-2 proteins Nsp6 and Orf9c with sigma receptors.

Ditolylguanidine is a sigma receptor (σR) agonist with neuroprotective activity. It shows Kd values of 21.9 nM and 57.4 nM for σ2 and σ1 receptor respectively. Combined treatment with Ditolylguanidine (5 mg/kg) and memantine induces antidepressant-like effect in rats. Sigma receptor modulators are predicted to show activity against SARS-Cov-2, based on viral assay screens and interaction of the SARS-CoV-2 proteins Nsp6 and Orf9c with sigma receptors.

B3044 | Ditolylguanidine DataSheet

Alternate Name/Synonyms: DTG; DOTG; 1,3-Di-o-tolylguanidine; 1,2-bis(2-methylphenyl)guanidine; {imino[(2-methylphenyl)amino]methyl}(2-methylphenyl)amine; 1,3-di-ortho-tolyl-guanidine

Appearance: White to Off-White powder

Formulation:

CAS Number: 97-39-2

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₅H₁₇N₃

Molecular Weight: 239.32

Cell-Permeable?: FALSE

Purity: ≥98%

Solubilities: ~6 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A sigma receptor agonist with neuroprotective activity

MDL Number: MFCD00008513

PubChem CID: 7333

SMILES: CC1=CC=CC=C1NC(=NC2=CC=CC=C2C)N

InChi: InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)

InChi Key: OPNUROKCUBTKLF-UHFFFAOYSA-N