DKK1 Antibody [ApR04794G]

DKK1 Antibody [ApR04794G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M, Rat

Specificity: This DKK1 antibody is generated from a rabbit immunized with a recombinant protein of human DKK1.

Cellular Localisation: Secreted.

Molecular Weight: 28672

Clone: Polyclonal

Gene Name: DKK1

Gene ID: 22943

Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856) . DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291) . Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity) .

Summary: Tissue Location: Placenta.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: IHC-P-Leica, IF, WB

Dilution: IHC-P-Leica--1:500 IF--1:25 WB--1:1000

Synonyms: Dickkopf-related protein 1, Dickkopf-1, Dkk-1, hDkk-1, SK, DKK1