DKK1 polyclonal Antibody | BS90413

DKK1 polyclonal Antibody | BS90413 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Rat

Application: WB ICC/IF IHC FC

Application Range: WB:1:1,000 ICC:1:50-1:500 IHC:1:50-1:200 FC:1:50-1:100

Background: The Wnt genes are a group of well conserved, cysteine-rich secreted glycoproteins that are required for numerous developmental processes including embryogenesis, asymmetric cell division and central nervous system (CNS) patterning. Wnt association with the seven membrane spanning receptor frizzled activates dishevelled, which downregulates glycogen synthase kinase (GSK) through serine phosphorylation, causing the accumulation of b-catenin and subsequent regulation of developmentally significant Wnt |target genes. The Dickkopf family of secreted inhibitors of Wnt signaling ensures proper morphological development by antagonizing different stages of the Wnt cascade. Dkk-1 (Dickkopf-1) acts upstream of b-catenin and dishevelled to inhibit Wnt signaling. Dkk-1 is a 266-amino acid (human), secreted protein that contains a 31-residue N-terminal signal peptide, 2 cysteine rich domains, and a putative carboxy terminal N-glycosylation site. Human Dkk-1 transcripts are abundantly present in fetal kidney, adult placenta and adult prostate. Putative cis regulatory elements upstream of the Dkk-1 start site include p53, Sp1, MyoD, STAT, Oct-1/2, C/EBP-a, C/EBP-b, GATA-1, GATA-2 and GATA-3.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: DKK1 polyclonal Antibody detects endogenous levels of DKK1 protein.

Molecular Weight: 38 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Dickkopf-1, Dkk-1, hDkk-1, DKK1, Dickkopf 1, Dickkopf 1 homolog, Dickkopf 1 like, Dickkopf homolog 1, Dickkopf like protein 1, Dickkopf related protein 1, Dickkopf WNT signaling pathway inhibitor 1, Dickkopf-1, Dickkopf-related protein 1, DKK 1, Dkk-1, Dkk1, DKK1, hDkk 1, hDkk-1, SK,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: