DKK2 Antibody [AMM22258G]

DKK2 Antibody [AMM22258G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H, M

Specificity: This DKK2 antibody is generated from a mouse immunized with a recombinant protein of human DKK2.

Cellular Localisation: Secreted.

Molecular Weight: 28447

Clone: Monoclonal

Gene Name: DKK2

Gene ID: 27123

Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) .

Summary: Tissue Location: Expressed in heart, brain, skeletal muscle and lung

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Dickkopf-related protein 2, Dickkopf-2, Dkk-2, hDkk-2, DKK2