DLG1 Antibody (Center) [APR11085G]

DLG1 Antibody (Center) [APR11085G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This DLG1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 643-673 amino acids from the Central region of human DLG1.

Cellular Localisation: Membrane; Peripheral membrane protein. Basolateral cell membrane. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q62696}. Cell junction, synapse, postsynaptic density {ECO:0000250|UniProtKB:Q62696}. Cell junction, synapse {ECO:0000250|UniProtKB:Q62696}. Cell membrane, sarcolemma. Apical cell membrane. Cell junction. Cytoplasm Note=Colocalizes with EPB41 at regions of intercellular contacts Basolateral in epithelial cells (PubMed:12807908) . May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity) {ECO:0000250|UniProtKB:Q62696, ECO:0000269|PubMed:10859302, ECO:0000269|PubMed:12807908, ECO:0000269|PubMed:8922391, ECO:0000269|PubMed:9192623}

Molecular Weight: 100455

Clone: Polyclonal

Gene Name: DLG1 (HGNC:2900)

Gene ID: 1739

Function: Essential multidomain scaffolding protein required for normal development (By similarity) . Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497) .

Summary: Tissue Location: Abundantly expressed in atrial myocardium (at protein level) . Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level) . Expressed in the brain (at protein level) (PubMed:23676497) . Widely expressed, with isoforms displaying different expression profiles.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Disks large homolog 1, Synapse-associated protein 97, SAP-97, SAP97, hDlg, DLG1