DMAP1 Antibody | 18-605

DMAP1 Antibody | 18-605 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-305 of human DMAP1 (NP_061973.1) .

Research Area: Other

Tested Application: WB, IHC

Application: WB: 1:1000 - 1:4000
IHC: 1:50 - 1:200

Specificiy: N/A

Positive Control 1: SH-SY5Y

Positive Control 2: SW480

Positive Control 3: A375

Positive Control 4: HeLa

Positive Control 5: Jurkat

Positive Control 6: NIH/3T3

Molecular Weight: Observed: 60kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: DMAP1, EAF2, SWC4, MEAF2, DNMAP1, DNMTAP1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.