DMOG | 2216

A cell-permeable prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α; promotes cell survival under hypoxic conditions. DMOG posseses neuroprotective effect on NFG deprived cell cultures through preservation of glucose metabolism. DMOG also attenuates myocardial injury in a rabbit ischemia reperfusion model.

DMOG is a cell-permeable prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α; promotes cell survival under hypoxic conditions.

2216 | DMOG DataSheet

Alternate Name/Synonyms: N-(2-Methoxy-2-oxoacetyl)glycine methyl ester

Appearance: White solid

Formulation: N/A

CAS Number: 89464-63-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₆H₉NO₅

Molecular Weight: 175.14

Cell-Permeable?: Yes

Purity: ³98% by NMR

Solubilities: DMSO (100 mM) or H₂O (100 mM)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH) inhibitor

MDL Number: MFCD05865098

PubChem CID: 560326

SMILES: COC(=O)CNC(=O)C(=O)OC

InChi: InChI=1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)

InChi Key: BNJOZDZCRHCODO-UHFFFAOYSA-N