DNA methylation inhibitor, Dichlone | 2860

Dichlone, a popular pesticide and fungicide, acts as a potent DNA methylation inhibitor (EC₅₀ = 460 nM against Dnmt3A/3L catalytic complex). Dichlone efficiently reactivates YFP gene expression in a stable HEK293 cell line by promoter demethylation.

Dichlone, a popular pesticide and fungicide, acts as a potent DNA methylation inhibitor (EC₅₀ = 460 nM against Dnmt3A/3L catalytic complex). Dichlone efficiently reactivates YFP gene expression in a stable HEK293 cell line by promoter demethylation.

2860 | DNA methylation inhibitor, Dichlone DataSheet

Alternate Name/Synonyms: 2,3-Dichloro-1,4-naphthoquinone, Dichlon

Appearance: Yellow solid

Formulation: N/A

CAS Number: 117-80-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₄Cl₂O₂

Molecular Weight: 227.04

Cell-Permeable?: Yes

Purity: ≥95% by GC

Solubilities: DMSO or EtOH

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A DNA methylation inhibitor

MDL Number: MFCD00001677

PubChem CID: 8342

SMILES: C1=CC=C2C(=C1)C(=O)C(=C(C2=O)Cl)Cl

InChi: InChI=1S/C10H4Cl2O2/c11-7-8(12)10(14)6-4-2-1-3-5(6)9(7)13/h1-4H

InChi Key: SVPKNMBRVBMTLB-UHFFFAOYSA-N