DNA polymerase eta Polyclonal Antibody | E-AB-67345

DNA polymerase eta Polyclonal Antibody | E-AB-67345 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: POLH, RAD30, RAD30A, XP-V, XPV

Application: WB, IF

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Epigenetics and Nuclear Signaling

Background: This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant fusion protein of human DNA polymerase eta (NP_006493.1).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000 IF 1:50-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 46 kDa/78 kDa

Molecular Weight(Observed): 70 kDa